6-羟基-4,5-二氢-1H-苯并[b]氮杂革-2(3H)-酮合成路线 （共 4 条）
反应条件
sodium azide in various solvent(s)
T=60 - 65°C; Yields of byproduct given;
参考文献
Valderrama; Pessoa-Mahana; Tapia
Synthetic Communications, 1992 , vol. 22, # 4 p. 629 - 639
反应条件
1: PPA / 110 - 120 °C
2: boron tribromide / dichloromethane / 20 °C / |Inert atmosphere; |Cooling with ice
View Scheme
参考文献
Han, Rong-Bi; Shao, Yun-Peng; Wu, Hui-Fan; Zhang, Duo; Piao, Feng-Yu
Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 2810 - 2820
反应条件
1: sodium ethanolate; hydroxylamine hydrochloride / ethanol; water / |Reflux
2: PPA / 110 - 120 °C
3: boron tribromide / dichloromethane / 20 °C / |Inert atmosphere; |Cooling with ice
View Scheme
参考文献
Han, Rong-Bi; Shao, Yun-Peng; Wu, Hui-Fan; Zhang, Duo; Piao, Feng-Yu
Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 2810 - 2820
反应条件
sodium azide; trifluoroacetic acid
Heating;
参考文献
Ohno, Michihiro; Tanaka, Yoichiro; Miyamoto, Mitsuko; Takeda, Takahiro; Hoshi, Kazuhiro; Yamada, Naohiro; Ohtake, Atsushi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2005 - 2021
