(2R,4R)-4-甲基-2-哌啶甲酸乙酯合成路线 (共 8 条)
反应条件
10 palladium hydroxide on charcoal; hydrogen in ethanol T=20°C; P=760.051 Torr; 4 h;
参考文献
Ferraboschi, Patrizia; Mieri, Maria De; Grisenti, Paride; Lotz, Matthias; Nettekoven, Ulrike
Tetrahedron Asymmetry, 2011 , vol. 22, # 16-17 p. 1626 - 1631
反应条件
potassium carbonate in water; ethyl acetate T=15 - 20°C; 1 h;
参考文献
LUNDBECK PHARMACEUTICALS ITALY S.P.A.; Stivanello, Mariano; Huber, Florian Anton Martin; Ricci, Antonio
Patent: US2014/88310 A1, 2014 ;
Location in patent: Paragraph 0090 ;
反应条件
hydrogen; palladium hydroxide - carbon in ethanol P=760 Torr; Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 1337 - 1340
反应条件
1: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 2: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 1337 - 1340
反应条件
1: TFA, H2O / dimethylformamide / 30 h / Ambient temperature 2: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 3: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 1337 - 1340
反应条件
1: SL-M004-1; bis(norbornadiene)rhodium(I) tetrafluoroborate; methanesulfonic acid; hydrogen / ethanol / 18 h / 90 °C / 7500.75 Torr / Autoclave 2: 10 palladium hydroxide on charcoal; hydrogen / ethanol / 4 h / 20 °C / 760.05 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1626 - 1631
反应条件
1.1: acetic acid; sodium hypochlorite / water / 2 h / 0 - 10 °C 1.2: 0 - 20 °C 2.1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 3.1: water; dichloromethane / 0 - 20 °C 4.1: hydrogenchloride / water / 20 - 60 °C 5.1: thionyl chloride / 0 °C / |Reflux 6.1: ethanol; acetone / 0.5 h / 40 °C / |Resolution of racemate 7.1: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme
反应条件
1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 2: water; dichloromethane / 0 - 20 °C 3: hydrogenchloride / water / 20 - 60 °C 4: thionyl chloride / 0 °C / |Reflux 5: ethanol; acetone / 0.5 h / 40 °C / |Resolution of racemate 6: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme