4-氨基-3,5-二甲基苯腈合成路线 （共 6 条）
反应条件
in 1-methyl-pyrrolidin-2-one T=160°C;
参考文献
Gerritz, Samuel; Shi, Shuhao; Zhu, Shirong
Patent: US2006/287287 A1, 2006 ;
Location in patent: Page/Page column 34 ;
US 20060287287 A1
反应条件
palladium (II) trifluoroacetate; 2-(di-tert-butylphosphino)-1-(2,6-diisopropylphenyl)-1H-imidazole; sodium carbonate in N,N-dimethyl acetamide T=140°C; 16 h; Inert atmosphere;
参考文献
Schareina, Thomas; Jackstell, Ralf; Schulz, Thomas; Zapf, Alexander; Cotte, Alain; Gotta, Matthias; Beller, Matthias
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 4 p. 643 - 648
反应条件
copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide T=100°C; 24 h; Inert atmosphere;
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
1: sulfuric acid; boric acid; dihydrogen peroxide; potassium bromide / water / 3 h / 20 °C 2: copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine / N,N-dimethyl-formamide / 24 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 23 p. 10856 - 10869
反应条件
1: With sulfuric acid in water T=5°C; 2: With water; sodium nitrite T=80°C; 1.5 h; Cooling;
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
3 h; Heating / reflux;
2: With sodium hydroxide; water in tetrahydrofuran
参考文献
Gerritz, Samuel; Shi, Shuhao; Zhu, Shirong
Patent: US2006/287287 A1, 2006 ;
Location in patent: Page/Page column 34 ;
US 20060287287 A1
