2-吡啶-2-基喹啉-4-羧酸合成路线 （共 23 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Pd2(dba)2] in tetrahydrofuran
T=20°C; 18 h;
参考文献
Dumouchel, Sylvain; Mongin, Florence; Trecourt, Francois; Queguiner, Guy
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3877 - 3880
反应条件
1: 2-bromoquinoline With (nBu)3MgLi in tetrahydrofuran; diethyl ether; hexane
T=-30 - -10°C;
2: 2-bromo-pyridine With 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran; diethyl ether; hexane
T=-10 - 20°C; 19 h;
参考文献
Dumouchel, Sylvain; Mongin, Florence; Trecourt, Francois; Queguiner, Guy
Tetrahedron, 2003 , vol. 59, # 43 p. 8629 - 8640
反应条件
copper(I) oxide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium dichloride in N,N-dimethyl acetamide
T=150°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Li, Xinjian; Zou, Dapeng; Leng, Faqiang; Sun, Chunxia; Li, Jingya; Wu, Yangjie; Wu, Yusheng
Chemical Communications, 2013 , vol. 49, # 3 p. 312 - 314
反应条件
η5-cyclopentadienyl-η4-cycloocta-1,5-diene-cobalt(I) in toluene
T=120°C;
参考文献
Zucca, Antonio; Cordeschi, Diletta; Maidich, Luca; Pilo, Maria Itria; Masolo, Elisabetta; Stoccoro, Sergio; Cinellu, Maria Agostina; Galli, Simona
Inorganic Chemistry, 2013 , vol. 52, # 13 p. 7717 - 7731
反应条件
methylmagnesium bromide in tetrahydrofuran
0.25 h; Ambient temperature;
参考文献
Wakabhayashi; Tanaka; Kubo; Uenishi; Oae
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 12 p. 3848 - 3850
反应条件
methylmagnesium bromide in tetrahydrofuran
0.25 h; Ambient temperature;
参考文献
Wakabayashi, Shoji; Kubo, Yukihiro; Takeda, Takashi; Uenishi, Jun-ichi; Oae, Shigeru
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 7 p. 2338 - 2341
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
1.2: 2 h / -78 °C / |Inert atmosphere
1.3: 5 h / 20 °C / |Inert atmosphere
2.1: methanol / 15 h / 20 °C / |Inert atmosphere
3.1: PdCl2dcpp; copper(l) iodide; 2-methylamino-ethanol / N,N-dimethyl-formamide / 16 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Sakashita, Shohei; Takizawa, Miho; Sugai, Juugaku; Ito, Hajime; Yamamoto, Yasunori
Organic Letters, 2013 , vol. 15, # 17 p. 4308 - 4311
反应条件
diethyl ether
T=-20°C;
参考文献
Gilman et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1788,1790
反应条件
in tetrahydrofuran
3 h; Ambient temperature;
参考文献
Furukawa, Naomichi; Shibutani, Tadao; Fujihara, Hisashi
Tetrahedron Letters, 1987 , vol. 28, # 47 p. 5845 - 5848
反应条件
1: EtMgBr / tetrahydrofuran / 0.42 h / Ambient temperature
2: 62 percent / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Furukawa, Naomichi; Shibutani, Tadao; Fujihara, Hisashi
Tetrahedron Letters, 1987 , vol. 28, # 47 p. 5845 - 5848
