6-甲氧基-1H-吲唑-5-胺合成路线 （共 7 条）
参考文献
Davies
Journal of the Chemical Society, 1955 , p. 2412,2419
反应条件
1.1: potassium acetate / CHCl3 / 20 - 40 °C
1.2: isoamyl nitrite / CHCl3 / 60 °C
2.1: HCl / methanol / 80 °C
3.1: sodium nitrate; H2SO4 / H2O / 20 °C
4.1: SnCl2*2H2O; HCl / H2O / 20 °C
View Scheme
参考文献
Takami, Atsuya; Iwakubo, Masayuki; Okada, Yuji; Kawata, Takehisa; Odai, Hideharu; Takahashi, Nobuaki; Shindo, Kazutoshi; Kimura, Kaname; Tagami, Yoshimichi; Miyake, Mika; Fukushima, Kayoko; Inagaki, Masaki; Amano, Mutsuki; Kaibuchi, Kozo; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2115 - 2137
反应条件
1: sodium nitrate; H2SO4 / H2O / 20 °C
2: SnCl2*2H2O; HCl / H2O / 20 °C
View Scheme
参考文献
Takami, Atsuya; Iwakubo, Masayuki; Okada, Yuji; Kawata, Takehisa; Odai, Hideharu; Takahashi, Nobuaki; Shindo, Kazutoshi; Kimura, Kaname; Tagami, Yoshimichi; Miyake, Mika; Fukushima, Kayoko; Inagaki, Masaki; Amano, Mutsuki; Kaibuchi, Kozo; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2115 - 2137
反应条件
1: HCl / methanol / 80 °C
2: sodium nitrate; H2SO4 / H2O / 20 °C
3: SnCl2*2H2O; HCl / H2O / 20 °C
View Scheme
参考文献
Takami, Atsuya; Iwakubo, Masayuki; Okada, Yuji; Kawata, Takehisa; Odai, Hideharu; Takahashi, Nobuaki; Shindo, Kazutoshi; Kimura, Kaname; Tagami, Yoshimichi; Miyake, Mika; Fukushima, Kayoko; Inagaki, Masaki; Amano, Mutsuki; Kaibuchi, Kozo; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2115 - 2137
反应条件
1.1: potassium carbonate; acetic anhydride / chloroform; acetic acid / 40 °C
1.2: 60 °C
1.3: 2 h / 80 °C
2.1: hydrogenchloride; tin(ll) chloride / water / 4 h / 0 - 20 °C
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1.1: nitric acid; sulfuric acid / acetic acid / 3 h / 5 - 10 °C
2.1: potassium carbonate; acetic anhydride / chloroform; acetic acid / 40 °C
2.2: 60 °C
2.3: 2 h / 80 °C
3.1: hydrogenchloride; tin(ll) chloride / water / 4 h / 0 - 20 °C
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1: acetic acid / Diazotization
2: iron; ethanol
View Scheme
参考文献
Davies
Journal of the Chemical Society, 1955 , p. 2412,2419
