N-(3,5-二硝基苯甲酰)-DL-亮氨酸合成路线 （共 6 条）
反应条件
in anhydrous dichloroethane; water
T=20.84°C; pH=5.7 - 9; 10 h; Resolution of racemateCentrifugal contactor separatorsaq. phosphate buffer; optical yield given as percent ee;
参考文献
Schuur, Boelo; Hallett, Andrew J.; Winkelman, Jozef G.M.; De Vries, Johannes G.; Heeres, Hero J.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 911 - 914
反应条件
(S)-C20H28N2O2; sodium hydrogencarbonate; tetra(n-hexyl)-ammonium chloride in tetrachloromethane
T=20°C; Title compound not separated from byproducts.;
参考文献
Pirkle; Snyder
Organic letters, 2001 , vol. 3, # 12 p. 1821 - 1823
反应条件
(S)-N-pivaloyl-2-[p-(tolyl)aminocarbonyl]pyrrolidine; sodium hydrogencarbonate in tetrachloromethane
T=20°C; Title compound not separated from byproducts;
参考文献
Snyder, Seth E.; Carey, James R.; Pirkle, William H.
Tetrahedron, 2005 , vol. 61, # 31 p. 7562 - 7567
反应条件
(S)-N-pivaloyl-2-[p-(tolyl)aminocarbonyl]pyrrolidine; sodium hydrogencarbonate in hexane
T=20°C; Title compound not separated from byproducts;
参考文献
Snyder, Seth E.; Carey, James R.; Pirkle, William H.
Tetrahedron, 2005 , vol. 61, # 31 p. 7562 - 7567
反应条件
1: DNB-(RS)-Leu With (S)-N-pivaloyl-2-[p-(tolyl)aminocarbonyl]pyrrolidine; (C6H13)4NCl in hexane
T=20°C;
2: α-bromoacetophenone Title compound not separated from byproducts;
参考文献
Snyder, Seth E.; Carey, James R.; Pirkle, William H.
Tetrahedron, 2005 , vol. 61, # 31 p. 7562 - 7567
反应条件
(S)-N-pivaloyl-2-[p-(tolyl)aminocarbonyl]pyrrolidine; (C6H13)4NBr; sodium hydrogencarbonate in decane; water
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Snyder, Seth E.; Carey, James R.; Pirkle, William H.
Tetrahedron, 2005 , vol. 61, # 31 p. 7562 - 7567
