3-(4-氟苯基)-2-丙炔醛合成路线 （共 9 条）
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, RT 2: 72 percent / 10percent chromic acid / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Wadsworth, Donald H.; Geer, Susan M.; Detty, Michael R.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3662 - 3668
反应条件
4-(N,N-dimethlyamino)pyridine; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride in toluene T=60°C; 2 h;
参考文献
Zeitler, Kirsten
Organic Letters, 2006 , vol. 8, # 4 p. 637 - 640
反应条件
1: 1-ethynyl-4-fluorobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-40°C; 0.25 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-40 - 20°C; 1 h;
3: With sodium dihydrogenphosphate in tetrahydrofuran; hexane; tert-butyl methyl ether; water
参考文献
Romanov-Michailidis, Fedor; Besnard, Celine; Alexakis, Alexandre
Organic Letters, 2012 , vol. 14, # 18 p. 4906 - 4909,4
Title/Abstract Show Details
Romanov-Michailidis, Fedor; Besnard, Celine; Alexakis, Alexandre
Organic Letters, 2012 , vol. 14, # 18 p. 4906 - 4909
反应条件
pyridinium chlorochromate in dichloromethane
1.5 h; Ambient temperature;
参考文献
Wadsworth, Donald H.; Geer, Susan M.; Detty, Michael R.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3662 - 3668
反应条件
in N,N-dimethyl-formamide
T=70 - 80°C; 12 h;
参考文献
Lee, Ka Young; Lee, Mi Jung; GowriSankar, Saravanan; Kim, Jae Nyoung
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5043 - 5046
反应条件
1: 1.) AlCl3, 3.) NaHCO3
2: 1 N aq. HCl / CH2Cl2
3: 72 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / -78 °C
4: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Wadsworth, Donald H.; Geer, Susan M.; Detty, Michael R.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3662 - 3668
反应条件
1: 72 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / -78 °C
2: 55 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / Ambient temperature
View Scheme
参考文献
Wadsworth, Donald H.; Geer, Susan M.; Detty, Michael R.
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3662 - 3668
反应条件
1: 4-Fluoro-β,β'-dibromostyrene With n-butyllithium
T=-78°C; Corey-Fuchs reaction;
2: N,N-dimethyl-formamide Corey-Fuchs reaction;
3: With potassium dihydrogenphosphate; water
Corey-Fuchs reaction;
参考文献
Zheng, Weihong; Degterev, Alexei; Hsu, Emily; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 4932 - 4935
反应条件
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 20 °C / |Inert atmosphere; |Schlenk technique
2: manganese(IV) oxide / dichloromethane / 20 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Song, Bo; Li, Lian-Hua; Song, Xian-Rong; Qiu, Yi-Feng; Zhong, Mei-Jin; Zhou, Ping-Xin; Liang, Yong-Min
Chemistry - A European Journal, 2014 , vol. 20, # 20 p. 5910 - 5913
