2,6-二甲基-5-甲氧羰基-4-(3-硝基苯基)-1,4-二氢吡啶-3-羧酸合成路线 (共 16 条)
反应条件
sodium hydroxide in methanol; water 9 h; Reflux;
参考文献
Zhang, Bang-le; He, Wei; Shi, Xin; Huan, Meng-lei; Huang, Qiu-ju; Zhou, Si-yuan
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 805 - 808
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide 5 h; Ambient temperature;
参考文献
Ogawa; Hatayama; Maeda; Kita
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 8 p. 1579 - 1589
反应条件
sodium hydroxide in methanol; water
参考文献
LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
Patent: US4769465 A1, 1988 ;
反应条件
hydrogenchloride; sodium hydroxide in water; acetone
反应条件
Calcium chloride in methanol; water
反应条件
Calcium chloride in methanol; water
反应条件
1: propan-2-ol / 5 h / Heating 2: 88 percent / Bu4NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 8 p. 1579 - 1589
反应条件
1: 99 percent / CHCl3 / Heating 2: 72 percent / NaOH / H2O / 40 °C View Scheme
参考文献
Synthetic Communications, , vol. 27, # 19 p. 3321 - 3331
反应条件
1: propan-2-ol / 5 h / Heating 2: 88 percent / Bu4NF / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 8 p. 1579 - 1589
反应条件
formic acid; palladium diacetate; triphenylphosphine
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 9 p. 3147 - 3158