2,6-二甲基-5-甲氧羰基-4-(3-硝基苯基)-1,4-二氢吡啶-3-羧酸合成路线 （共 16 条）
反应条件
biotransformation in rat, dog, and mouse (in vivo and in vitro);
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 41, # 10 p. 1009 - 1021
反应条件
1: 1,4-dihydro-2,6-dimethyl-5-methoxy-carbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide in dichloromethane 1 h; Sonographic reactionCooling with ice; 2: 3-hydroxy-N-phenylmethylpiperidine in dichloromethane 2.5 h; Cooling with iceSonographic reaction;
参考文献
HEFEI BEINI MEDICAL TECHNOLOGY COMPANY, LTD; ZHANG, Zhaoyong
Patent: WO2012/142815 A1, 2012 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
1: SOCl2 / dimethylformamide; CH2Cl2 / 1 h 2: dimethylformamide; CH2Cl2 / 2.5 h View Scheme
参考文献
Muto; Kuroda; Kawato; Karasawa; Kubo; Nakamizo
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 11 A p. 1662 - 1665
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in toluene T=20 - 75°C; 2 h;
参考文献
CIPLA LIMITED
Patent: US2012/232091 A1, 2012 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: SOCl2 / CH2Cl2; dimethylformamide / 1 h / 0 - 5 °C 2: dimethylformamide; CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Leonardi, Amedeo; Motta, Gianni; Pennini, Renzo; Testa, Rodolfo; Sironi, Giorgio; Catto, Alberto; Cerri, Alberto; Zappa, Marco; Bianchi, Giorgio; Nardi, Dante
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 399 - 420
反应条件
1: CN / water; N,N-dimethyl-formamide / 24 h / 20 - 120 °C
2: phosphorus pentachloride / dichloromethane / 1 h / -20 °C
3: dichloromethane / 4 h / -30 °C
View Scheme
参考文献
Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya
Molecules, 2014 , vol. 19, # 1 p. 1344 - 1352
