2-氯-1,1,1-三甲氧基乙烷合成路线 （共 30 条）
反应条件
in ethanol T=80°C; 3 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2005/245500 A1, 2005 ;
Location in patent: Page/Page column 31 ;
US 20050245500 A1
反应条件
T=160°C; 0.0833333 h; microwave irradiation;
参考文献
Natero, Reina; Koltun, Dmitry O.; Zablocki, Jeffery A.
Synthetic Communications, 2004 , vol. 34, # 14 p. 2523 - 2529
反应条件
T=160°C; 0.0833333 h; microwave irradiation;
参考文献
Natero, Reina; Koltun, Dmitry O.; Zablocki, Jeffery A.
Synthetic Communications, 2004 , vol. 34, # 14 p. 2523 - 2529
反应条件
in methanol T=20°C; 72 h;
参考文献
Cowden; Wilson; Bishop; Cottrell; Davies; Dolling
Tetrahedron Letters, 2000 , vol. 41, # 44 p. 8661 - 8664
反应条件
in methanol; toluene
参考文献
Cowden, Cameron John
Patent: US2003/187274 A1, 2003 ;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2009/67233 A1, 2009 ;
Location in patent: Page/Page column 69 ;
反应条件
acetic acid T=160°C; 0.5 h; Microwave;
参考文献
CV THERAPEUTICS, INC.
Patent: WO2009/94028 A1, 2009 ;
Location in patent: Page/Page column 54 ;
WO 2009/094028 A1
反应条件
acetic acid in toluene 17 h; Reflux;
参考文献
ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB
Patent: WO2009/153536 A1, 2009 ;
Location in patent: Page/Page column 37-38 ;
WO 2009/153536 A1
反应条件
in hydrogenchloride T=25°C; Thermodynamic data;
参考文献
Guthrie, J.Peter; Cullimore, Patricia A.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 1281 - 1294
反应条件
toluene-4-sulfonic acid in ethanol T=65°C; 22 h;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
