2-氰基-3-(1-萘)丙烯酸乙酯合成路线 (共 8 条)
反应条件
piperidine; acetic acid in benzene
3 h; Heating;
参考文献
Harada; Iizuka; Kamijo; Akahane; Yamamoto; Nakano; Tsubaki; Kubota; Shimaoka; Umeyama; Kiso
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 3042 - 3047
参考文献
Hopkins; Chisholm; Michael
Canadian Journal of Research, Section B: Chemical Sciences, 1945 , vol. 23, p. 84,85
反应条件
2: aq.-ethanolic KOH
View Scheme
参考文献
Newman; Flanagan
Journal of Organic Chemistry, 1958 , vol. 23, p. 796
反应条件
in tetrahydrofuran
1 h;
参考文献
WYETH
Patent: WO2004/99150 A2, 2004 ;
Location in patent: Page 48-49 ;
WO 2004/099150 A2
反应条件
in tetrahydrofuran
1 h;
参考文献
Caggiano, Thomas J.; Brazzale, Antony; Ho, Douglas M.; Kraml, Christina M.; Trybulski, Eugene; Chadwick, Christopher C.; Chippari, Sue; Borges-Marcucci, Lisa; Eckert, Amy; Keith, James C.; Kenney, Thomas; Harnish, Douglas C.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5245 - 5248
反应条件
magnesium
2.) ether, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Fadda; Badawy; Elmorsy
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 2 p. 171 - 173
参考文献
Newman; Flanagan
Journal of Organic Chemistry, 1958 , vol. 23, p. 796
参考文献
Le Moal,H. et al.
Bulletin de la Societe Chimique de France, 1964 , p. 579 - 584