8-羟基-2-氧代-1-氮杂螺[4.5]-7-癸烯-7-羧酸甲酯合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol T=100°C; 3.5 h;
参考文献
Ieda, Shigeru; Asoh, Yusuke; Fujimoto, Teppei; Kitaoka, Haruka; Kan, Toshiyuki; Fukuyama, Tohru
Heterocycles, 2009 , vol. 79, # C p. 721 - 738
反应条件
methanol; sodium hydride in benzene
T=90°C; Dieckmann condensation; 0.5 h;
参考文献
Ieda, Shigeru; Asoh, Yusuke; Fujimoto, Teppei; Kitaoka, Haruka; Kan, Toshiyuki; Fukuyama, Tohru
Heterocycles, 2009 , vol. 79, # C p. 721 - 738
反应条件
1: H2 / Ra-Ni(W2) / methanol / 6 h / 20 °C / 3677.54 Torr
2: 12.8 g / NaH; MeOH / benzene / 0.5 h / 90 °C
View Scheme
参考文献
Kan, Toshiyuki; Fujimoto, Teppei; Ieda, Shigeru; Asoh, Yusuke; Kitaoka, Haruka; Fukuyama, Tohru
Organic Letters, 2004 , vol. 6, # 16 p. 2729 - 2731
反应条件
1: aq. NaOH / methanol / 3.5 h / 100 °C
2: CSA / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Kan, Toshiyuki; Fujimoto, Teppei; Ieda, Shigeru; Asoh, Yusuke; Kitaoka, Haruka; Fukuyama, Tohru
Organic Letters, 2004 , vol. 6, # 16 p. 2729 - 2731
