3-氯-2-(三氟甲基)吡啶-4-羧酸合成路线 （共 4 条）
反应条件
1: 3-chloro-2-(trifluoromethyl)pyridine With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-75°C; 2 h;
2: carbon dioxide in tetrahydrofuran; hexane
参考文献
Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred
Synthesis, 2004 , # 10 p. 1619 - 1624
参考文献
TAISHO PHARMACEUTICAL CO., LTD.
Patent: WO2008/18639 A2, 2008 ;
Location in patent: Page/Page column 109 ;
WO 2008/018639 A2
反应条件
1.1: 46 percent / KF; CuI / 1-methyl-pyrrolidin-2-one / 6 h / 50 °C
2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 81 percent / tetrahydrofuran; hexane
View Scheme
参考文献
Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred
Synthesis, 2004 , # 10 p. 1619 - 1624
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C
2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 81 percent / tetrahydrofuran; hexane
View Scheme
参考文献
Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred
Synthesis, 2004 , # 10 p. 1619 - 1624
