lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 2 h;

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C 2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 81 percent / tetrahydrofuran; hexane View Scheme