5-溴-2-三氟甲基-异烟酸合成路线 (共 1 条)
反应条件
1: 5-bromo-2-(trifluoromethyl)pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78 - -60°C; 0.0166667 h; Cooling with acetone-dry ice; 2: carbon dioxide in tetrahydrofuran; hexanes T=-78 - 20°C; 1 h; Cooling with acetone-dry ice; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2008/124610 A1, 2008 ;
Location in patent: Page/Page column 43; 44 ;
WO 2008/124610 A1