乙基3-(2-硫代-1-吡咯烷基)丙酸酯合成路线 （共 3 条）
反应条件
1: 2.) Ph3P, Et3N / 1.) CH3CN, room temperature, 16h; 2.) CH3CN,room temperature;
2: 90 percent / H2 / PtO2 / acetic acid
View Scheme
参考文献
Howard, Arthur S.; Gerrans, Graeme C.; Meerholz, Clive A.
Tetrahedron Letters, 1980 , vol. 21, p. 1373 - 1374
反应条件
1: tetrahydrofuran / 17 h / 0 °C
2: Et3N / CH2Cl2 / 72 h / 20 °C
3: KOH / ethanol / 0.5 h / Heating
4: 183 mg / Ac2O; K2CO3 / acetonitrile / 23 h
5: 77 percent / sodium amalgam; Na2HPO4 / tetrahydrofuran; methanol / 14 h
View Scheme
参考文献
Howard, Arthur S.; Gerrans, Graeme C.; Meerholz, Clive A.
Tetrahedron Letters, 1980 , vol. 21, p. 1373 - 1374
反应条件
1: tetrahydrofuran / 17 h / 0 °C
2: Et3N / CH2Cl2 / 72 h / 20 °C
3: 94 percent / LiAlH4 / tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Michael, Joseph P.; De Koning, Charles R.; Malefetse, Tshepo J.; Yillah, Ibrahim
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3510 - 3517
