3-(4-溴-2-氟苯基)-5-甲基-1,2,4-噁二唑合成路线 （共 3 条）
反应条件
1: 4-cyano-3-fluoro-1-bromobenzene With hydroxylamine hydrochloride; potassium carbonate in ethanol
24 h; Heating / reflux;
2: acetic anhydride in pyridine
T=20°C; 17 h; Heating / reflux;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 23 ;
US 20050176701 A1
反应条件
sodium hydride in tetrahydrofuran
T=60°C; 15 h; Molecular sieveHeating / reflux;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/38100 A1, 2006 ;
Location in patent: Page/Page column 75 ;
反应条件
in pyridine
T=20°C; 17 h; Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2004/74270 A2, 2004 ;
Location in patent: Page 50 ;
