N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide in water T=40°C; 9 h;

1: (4-Bromo-2-fluoro-phenyl)-acetonitrile With sodium hydride in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=0°C; 2: ethylene dibromide in tetrahydrofuran; DMF (N,N-dimethyl-formamide) 0.5 h;

1: (4-Bromo-2-fluoro-phenyl)-acetonitrile With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil 0.5 h; Inert atmosphereCooling with ice; 2: ethylene dibromide in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil T=20°C; 3 h; Inert atmosphereCooling with ice;

1: water; ethanol / 8.5 h / 100 °C 2: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 9 h / 40 °C View Scheme

water; potassium hydroxide in ethanol 7 h; Reflux;