4-[2-[2-环戊基-5-[(5,7-二甲基[1,2,4]噻唑并[1,5-a]嘧啶)甲基]-3,6-二氢-4-羟基-6-氧代-2H-吡喃]乙基]-2-氟-α,α-二甲基苯乙腈合成路线 （共 6 条）
反应条件
dimethylsulfide borane complex in methanol
T=25°C; 3 h;
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
反应条件
1: 3.6 g / CsF / methanol / 25 °C
2: diisopropylamine / bis(triphenylphosphine)palladium (II) dichloride; CuI / dimethylformamide / 0.33 h / 90 °C / sonification
3: H2 / Pd(OH)2/C / ethanol / 6 h / 25 °C
4: 0.614 g / NaOH / methanol / 3 h / 25 °C
5: 80 percent / BH3*SMe2 / methanol / 3 h / 25 °C
View Scheme
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
反应条件
1: diisopropylamine / bis(triphenylphosphine)palladium (II) dichloride; CuI / dimethylformamide / 0.33 h / 90 °C / sonification
2: H2 / Pd(OH)2/C / ethanol / 6 h / 25 °C
3: 0.614 g / NaOH / methanol / 3 h / 25 °C
4: 80 percent / BH3*SMe2 / methanol / 3 h / 25 °C
View Scheme
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
反应条件
1: H2 / Pd(OH)2/C / ethanol / 6 h / 25 °C
2: 0.614 g / NaOH / methanol / 3 h / 25 °C
3: 80 percent / BH3*SMe2 / methanol / 3 h / 25 °C
View Scheme
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
反应条件
1.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 - -30 °C
2.1: 3.6 g / CsF / methanol / 25 °C
3.1: diisopropylamine / bis(triphenylphosphine)palladium (II) dichloride; CuI / dimethylformamide / 0.33 h / 90 °C / sonification
4.1: H2 / Pd(OH)2/C / ethanol / 6 h / 25 °C
5.1: 0.614 g / NaOH / methanol / 3 h / 25 °C
6.1: 80 percent / BH3*SMe2 / methanol / 3 h / 25 °C
View Scheme
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
反应条件
1: 0.614 g / NaOH / methanol / 3 h / 25 °C
2: 80 percent / BH3*SMe2 / methanol / 3 h / 25 °C
View Scheme
参考文献
Li, Hui; Linton, Angelica; Tatlock, John; Gonzalez, Javier; Borchardt, Allen; Abreo, Mel; Jewell, Tanya; Patel, Leena; Drowns, Matthew; Ludlum, Sarah; Goble, Mike; Yang, Michele; Blazel, Julie; Rahavendran, Ravi; Skor, Heather; Shi, Stephanie; Lewis, Cristina; Fuhrman, Sheila
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 3969 - 3972
