1: With sodium methylate in dimethyl sulfoxide T=110°C; 2 h; 2: With water in dimethyl sulfoxide; acetonitrile T=15°C; 3: With hydrogenchloride in water; dimethyl sulfoxide; acetonitrile T=20°C; pH=7.9;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/111046 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
Bellamy, Anthony J.; Kerr, John B.; McGregor, CChristopher J.; MacKirdy, Iain S.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 161 - 168
0.1 M Et4BF4 in N,N-dimethyl-formamide T=21 - 24°C; electrochemical process; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bellamy, Anthony J.; Kerr, John B.; McGregor, CChristopher J.; MacKirdy, Iain S.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 161 - 168
tetraethyl ammonium fluoride T=21 - 24°C; 0.333333 h; electrochemical process; various temp., concentrations and water addition; Product distribution;
参考文献
Bellamy, Anthony J.; Kerr, John B.; McGregor, CChristopher J.; MacKirdy, Iain S.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 161 - 168
