1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78 - 0°C; 5 h;
2: acetaldehyde in tetrahydrofuran; hexane
T=-78 - 20°C; 21 h;
3: With water in tetrahydrofuran; hexane
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2009/156642 A1, 2009 ;
Location in patent: Page/Page column 40 ;
Bowen, Richard D.; Colburn, Alex W.; Derrick, Peter J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 1 p. 147 - 151