1: 1-cycloheptene With ozone in methanol
T=-78°C; 0.75 h;
2: With toluene-4-sulfonic acid in methanol
T=-78 - 0°C; 2 h;
3: dimethylsulfide With sodium hydrogencarbonate
more than 3 stages;
参考文献
THERAVANCE, INC.
Patent: WO2005/7645 A1, 2005 ;
Location in patent: Page 81 ;
WO 2005/007645 A1
