1: methyl 3-hydroxy-2-methylidene-propanoate With magnesium iodide in dichloromethane
Cooling with acetone-dry iceInert atmosphere;
2: 2-iodo-propane With triethyl borane; tri-n-butyl-tin hydride in hexane; dichloromethane
T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Korea Institute of Science and Technology; MIN, Sun Joon; Cho, Yong Seo; Lee, Jae Kyun; Pae, Ae Nim; Son, Young Wook
Patent: US2013/197227 A1, 2013 ;
Location in patent: Paragraph 0035; 0036; 0037 ;
Cristau, Henri-Jean; Garcia, Chantal; Kadoura, Jumah; Torreilles, Eliane
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 49/50, p. 151 - 154