2,2,2-三氟乙醇合成路线 （共 1089 条）
反应条件
sodium carbonate T=50°C; 144 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 16 h; Inert atmosphereCooling with ice;
参考文献
Messik, Frauke; Oberthuer, Markus
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0771-PSP, p. 167 - 170
反应条件
1: 2,2,2-trifluoroethanol With potassium carbonate in N,N-dimethyl-formamide T=50 - 55°C; Large scale reaction; 2: (R)-(+)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole in N,N-dimethyl-formamide T=25 - 95°C; Large scale reaction;
参考文献
Raju, Manne Naga; Kumar, Neelam Uday; Reddy, Baddam Sudhakar; Anitha, Naredla; Srinivas, Gangula; Bhattacharya, Apurba; Mukkanti, Kagga; Kolla, Naveenkumar; Bandichhor, Rakeshwar
Tetrahedron Letters, 2011 , vol. 52, # 42 p. 5464 - 5466
反应条件
4-methyl-morpholine T=65°C; alcoholysis, cyclization; Product distribution; Further Variations:equivalent of N-methylmorpholine;
参考文献
Zhu, Jiang; Bennet, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4423 - 4430
反应条件
4-methyl-morpholine; water T=65°C; Hydrolysis; alcoholysis; Product distributionKinetics; Further Variations:trifluoroethanol/water ratio;
参考文献
Zhu, Jiang; Bennet, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4423 - 4430
反应条件
4-methyl-morpholine T=65°C; alcoholysis; Product distribution;
参考文献
Zhu, Jiang; Bennet, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4423 - 4430
反应条件
4-methyl-morpholine T=65°C; alcoholysis; Product distributionKinetics; Further Variations:Reaction partnersCF3CH2OH/EtOH ratio;
参考文献
Zhu, Jiang; Bennet, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4423 - 4430
反应条件
4-methyl-morpholine; water T=65°C; Hydrolysis; alcoholysis; Product distribution;
参考文献
Zhu, Jiang; Bennet, Andrew J.
Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4423 - 4430
反应条件
water T=25°C; deuterium isotope effect in solvolysis; Product distributionRate constant;
参考文献
Shiner, V. J.; Tai, Jimmy J.
Journal of the American Chemical Society, 1981 , vol. 103, # 2 p. 436 - 442
反应条件
water T=-10°C; Kinetics;
参考文献
Bentley, T. William; Harris, H. Carl; Ryu, Zoon Ha; Lim, Gui Taek; Sung, Dae Dong; Szajda, Stanley R.
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8963 - 8970
