2,2,2-三氟乙醇合成路线 （共 1089 条）
反应条件
1: triphenylphosphine With bromine in dichloromethane
T=-78°C; 0.166667 h; Inert atmosphere;
2: 2,2,2-trifluoroethanol With triethylamine in diethyl ether; dichloromethane
T=-78 - 20°C; 1.25 h; Inert atmosphere;
参考文献
Morieux, Pierre; Salome, Christophe; Park, Ki Duk; Stables, James P.; Kohn, Harold
Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5716 - 5726
参考文献
Yang, Zhen-Yu
Journal of Organic Chemistry, 1995 , vol. 60, p. 5696 - 5698
反应条件
1: 2,2,2-trifluoroethanol With sodium hydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: benzyl bromide in tetrahydrofuran
T=65°C; 3 h; Inert atmosphere;
参考文献
Yang, Qingliang; Njardarson, Jon T.
Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7080 - 7082
反应条件
sodium acetate in water
T=42°C;
参考文献
Maskill, H.
Journal of the Chemical Society, Chemical Communications, 1986 , p. 1433 - 1435
反应条件
sodium carbonate
Heating;
参考文献
da Roza,D.A. et al.
Journal of the American Chemical Society, 1973 , vol. 95, p. 7003 - 7009
反应条件
water
T=42°C; rate effects of SCN(1-) at the solvolysis; Product distribution;
参考文献
Maskill, H.; Jencks, William P.
Journal of the American Chemical Society, 1987 , vol. 109, # 7 p. 2062 - 2070
反应条件
water; sodium acetate
T=42°C; products from solvolysis, containing unbuffered or buffered sodium acetate; Product distribution;
参考文献
Maskill, H.; Jencks, William P.
Journal of the American Chemical Society, 1987 , vol. 109, # 7 p. 2062 - 2070
反应条件
water
T=42°C; products from solvolysis in the presence of imidazole buffers; Product distribution;
参考文献
Maskill, H.; Jencks, William P.
Journal of the American Chemical Society, 1987 , vol. 109, # 7 p. 2062 - 2070
反应条件
water
T=42°C; products from solvolysis , effects of ethanol and sodium thiocyanate; Product distribution;
参考文献
Maskill, H.; Jencks, William P.
Journal of the American Chemical Society, 1987 , vol. 109, # 7 p. 2062 - 2070
反应条件
also with NaOAc or imidazole in water
T=42°C; MechanismProduct distributionRate constant;
参考文献
Maskill, H.
Journal of the Chemical Society, Chemical Communications, 1986 , p. 1433 - 1435
