2-{2-[2-(2-羟基乙氧基)乙氧基]乙基}-1H-异吲哚-1,3(2H)-二酮合成路线 （共 13 条）
反应条件
1: 70 percent / hydrazine hydrate / ethanol / 3 h / Heating 2: 55 percent / Na2CO3 / 36 h / 110 °C 3: 49 percent Spectr. / toluenesulphonyl chloride, NaOH / dioxane / 5 h / 60 °C / variation of base View Scheme
参考文献
Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo
Tetrahedron, 1982 , vol. 38, # 22 p. 3359 - 3362
反应条件
1: 70 percent / hydrazine hydrate / ethanol / 3 h / Heating 2: 55 percent / Na2CO3 / 36 h / 110 °C View Scheme
参考文献
Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo
Tetrahedron, 1982 , vol. 38, # 22 p. 3359 - 3362
反应条件
hydrazine hydrate in ethanol 3 h; Reflux;
参考文献
Yerramreddy, Thirupathi Reddy; Milewski, Mikolaj; Penthala, Narsimha Reddy; Stinchcomb, Audra L.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3280 - 3283
反应条件
1: 1.1 g / Jones reagent / acetone / 0.5 h 2: 1.) hydrazine hydrate; 2.) cc. hydrochloric acid / 1.) methanol, reflux, 3 h; 2.) water View Scheme
参考文献
Slama, James; Rando, Robert R.
Carbohydrate Research, 1981 , vol. 88, p. 213 - 222
反应条件
1: hydrazine / ethanol / Inert atmosphere 2: sodium hydrogencarbonate / water / Inert atmosphere 3: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / dichloromethane / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 32 p. 12382 - 12385
反应条件
in N,N-dimethyl-formamide
T=100°C; 18 h;
参考文献
Lu, Genliang; Lam, Sang; Burgess, Kevin
Chemical Communications, 2006 , # 15 p. 1652 - 1654
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide
T=80°C; Substitution; 18 h;
参考文献
Ossipov, Dimitri; Zamaratski, Edouard; Chattopadhyava, Jyoti
Helvetica Chimica Acta, 1999 , vol. 82, # 12 p. 2186 - 2200
反应条件
PTC in toluene
T=100°C; 4 h; Inert atmosphere;
参考文献
Li, Liwen; Zhang, Qiu; Liu, Aifeng; Li, Xiue; Zhou, Hongyu; Liu, Yin; Yan, Bing
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6886 - 6889
反应条件
1: 58.3 g / sodium iodide / butan-2-one / 19 h / Heating
2: 16.7 g / dimethylformamide / 18 h / 95 °C
View Scheme
参考文献
Slama, James; Rando, Robert R.
Carbohydrate Research, 1981 , vol. 88, p. 213 - 222
反应条件
in N,N-dimethyl-formamide
T=95°C; 18 h;
参考文献
Slama, James; Rando, Robert R.
Carbohydrate Research, 1981 , vol. 88, p. 213 - 222
