1-[4-(5-氨基-2-氟苯基)-1-哌嗪]乙酮合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal
Ambient temperature;
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 87 percent / dimethylformamide / 1 h / 80 - 90 °C
2: 44 percent / conc. H2SO4, 60percent HNO3 / 2 h / 10 °C
3: 100 percent / H2 / 10percent palladium on charcoal / Ambient temperature
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
in N-methyl-acetamide; water
参考文献
CENTRO MARGA PARA LA INVESTIGACION S.A.
Patent: EP376870 A1, 1990 ;
反应条件
1: 44 percent / conc. H2SO4, 60percent HNO3 / 2 h / 10 °C
2: 100 percent / H2 / 10percent palladium on charcoal / Ambient temperature
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
