1,4-二溴-2,3-二甲基苯合成路线 （共 5 条）
反应条件
in N,N-dimethyl-formamide 4 h; Heating;
参考文献
Lai, Yee-Hing; Yap, Angeline Hui-Tin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1373 - 1377
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 1418,1420
反应条件
1: With sodium carbonate in diethyl ether; water
2: With tert.-butylnitrite; copper(ll) bromide in acetonitrile
T=20 - 82°C; 20 h; Inert atmosphere;
参考文献
Maiereanu, Carmen; Schmitt, Celine; Schifano-Faux, Nadge; Le Nouen, Didier; Defoin, Albert; Tarnus, Celine
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5716 - 5733
反应条件
1: 34 percent / N-bromosuccinimide / dimethylformamide / 24 h / Ambient temperature
2: 1.) 48percent aq. HBr, aq. NaNO2, 2.) 48percent aq. HBr, CuBr / 2.) reflux, 30 min
View Scheme
参考文献
Lai, Yee-Hing; Yap, Angeline Hui-Tin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1373 - 1377
反应条件
hydrogen bromide; sodium nitrite
anschliessend Behandeln mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure;
参考文献
Cachia; Wahl
Bulletin de la Societe Chimique de France, 1958 , p. 1418,1420
