5-(二甲氨基亚甲基)-2,2-二甲基-1,3-二氧己环-4,6-二酮合成路线 （共 9 条）
反应条件
sodium methylate in tetrahydrofuran T=0 - 15°C; 18 h;
参考文献
Ziegler, Frederick E.; Guenther, Thomas; Nelson, Richard V.
Synthetic Communications, 1980 , vol. 10, # 9 p. 661 - 666
反应条件
in diethyl ether; acetone T=22 - 25°C; 1 h;
参考文献
Stezhko, T. V.; Solov'eva, N. P.; Kuleshova, E. F.; Granik, V. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , vol. 24, p. 151 - 153
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 2 p. 184 - 187
反应条件
in acetonitrile T=20°C; 0.5 h;
参考文献
McNab, Hamish; Monahan, Lilian C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 863 - 868
反应条件
acetic anhydride T=90°C; Condensation; 1 h;
参考文献
Synthesis, , # 12 p. 2103 - 2113
反应条件
oxalyl dichloride 1.) DMF, MeCN, -18 deg C, 15 min, 2.) MeCN, -18 deg C to 0 deg C, 15 min, 3.) pyridine, MeCN, 0 deg C, 1 h; room temperature, 3.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 3 p. 211 - 220
反应条件
sodium methylate; potassium carbonate 1.) MeOH, RT, 5 h, 2.) RT, overnight; Yield given. Multistep reaction;
参考文献
Blake, Alexander J.; McNab, Hamish; Monahan, Lilian C.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 12 p. 2003 - 2010
反应条件
hydrogenchloride 1.) ether, THF, 50 min;
参考文献
Ziegler, Frederick E.; Guenther, Thomas; Nelson, Richard V.
Synthetic Communications, 1980 , vol. 10, # 9 p. 661 - 666
反应条件
hydrogenchloride 1.) ether, THF;
参考文献
Ziegler, Frederick E.; Guenther, Thomas; Nelson, Richard V.
Synthetic Communications, 1980 , vol. 10, # 9 p. 661 - 666
反应条件
hydrogenchloride
1.) ether, THF;
参考文献
Ziegler, Frederick E.; Guenther, Thomas; Nelson, Richard V.
Synthetic Communications, 1980 , vol. 10, # 9 p. 661 - 666
