2-氰基-2-甲基丙酰胺合成路线 （共 12 条）
反应条件
1: With ammonia; Raney nickel in methanol T=25 - 35°C; Autoclave; 2: With hydrogen in methanol T=60 - 65°C; P=5149.01 - 5884.58 Torr; 10 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KOLLA, Naveen Kumar; APPAYE, Kaliyaperumal Srinivasan; GANGULA, Srinivas; GOVINDAPUR, Rajeshwar Reddy; MANNE, Nagaraju; NIKUMBH, Satish Pandurang; NEELAM, Uday Kumar; JOSEPH, Suju Chuttippari; BADDAM, Sudhakar Reddy; KUNHIMON, Shyam Kumar Unniaranpurakkal; MOOVENDAN, Mohan; DAHANUKAR, Vilas; DONIPARTHI, Kiran Kumar
Patent: WO2012/21446 A2, 2012 ;
Location in patent: Page/Page column 30-31 ;
反应条件
1.1: LAH / tetrahydrofuran 1.2: Et3N 2.1: H2 / Pd()OH)2/C 3.1: 65 percent / 2-hydroxypyridine; Et3N 4.1: TMSCl; phenol / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
potassium hypobromide
参考文献
Errera
Gazzetta Chimica Italiana, 1896 , vol. 26 I, p. 201
反应条件
1: hydrogen; ammonia / raney nickel / methanol / 14 h / 40 - 45 °C / 2942.29 Torr 2: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; RAMA SUBBA REDDY, Karamala; SAHADEVA REDDY, Maramreddy
Patent: WO2011/148392 A1, 2011 ;
反应条件
1: hydrogen; ammonia / raney nickel / methanol / 14 h / 40 - 45 °C / 2942.29 Torr 2: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C 3: hydrogen; ethanolamine / palladium 10 on activated carbon / isopropyl alcohol / 3 h 4: ethanol / 0.17 h / 25 - 30 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; RAMA SUBBA REDDY, Karamala; SAHADEVA REDDY, Maramreddy
Patent: WO2011/148392 A1, 2011 ;
反应条件
ammonia in methanol
T=20°C; 15 h;
参考文献
LEK PHARMACEUTICALS D.D.; JENKO, Branko; COPAR, Anton
Patent: WO2010/112482 A1, 2010 ;
Location in patent: Page/Page column 29 ;
反应条件
ammonia in methanol
T=25 - 30°C; 12 h;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; RAMA SUBBA REDDY, Karamala; SAHADEVA REDDY, Maramreddy
Patent: WO2011/148392 A1, 2011 ;
Location in patent: Page/Page column 64 ;
反应条件
T=140 - 150°C; P=0.3 Torr; 72 h;
参考文献
Feuer, Henry; Halasa, Adel F.
Polish Journal of Chemistry, 1981 , vol. 55, # 6 p. 1281 - 1288
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1.1: LAH / tetrahydrofuran
1.2: Et3N
2.1: H2 / Pd()OH)2/C
3.1: 65 percent / 2-hydroxypyridine; Et3N
View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KOLLA, Naveen Kumar; APPAYE, Kaliyaperumal Srinivasan; GANGULA, Srinivas; GOVINDAPUR, Rajeshwar Reddy; MANNE, Nagaraju; NIKUMBH, Satish Pandurang; NEELAM, Uday Kumar; JOSEPH, Suju Chuttippari; BADDAM, Sudhakar Reddy; KUNHIMON, Shyam Kumar Unniaranpurakkal; MOOVENDAN, Mohan; DAHANUKAR, Vilas; DONIPARTHI, Kiran Kumar
Patent: WO2012/21446 A2, 2012 ;
