2-己基-3-甲基马来酸酐合成路线 （共 9 条）
反应条件
copper(l) iodide in N,N,N',N',N'',N''-hexamethylphosphoric triamide; diethyl ether
T=-5 - 20°C; 8 h;
参考文献
Deshpande, Anil M.; Natu, Arvind A.; Argade, Narshinha P.
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9557 - 9558
反应条件
1: 60 percent / NBS, benzoyl peroxide / CCl4 / 10 h / Heating
2: CuI / diethyl ether; hexamethylphosphoric acid triamide / 8 h / -5 - 20 °C
View Scheme
参考文献
Deshpande, Anil M.; Natu, Arvind A.; Argade, Narshinha P.
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9557 - 9558
反应条件
1.1: 98 percent / aq. methanesulfonic acid / 6 h / 100 °C
2.1: KOH / methanol; tetrahydrofuran / 2 h / Heating
2.2: 67 percent / aq. acid
View Scheme
参考文献
De Buyck, Laurent; Cagnoli, Rita; Ghelfi, Franco; Merighi, Giulia; Mucci, Adele; Pagnoni, Ugo M.; Parsons, Andrew F.
Synthesis, 2004 , # 10 p. 1680 - 1686
反应条件
1: DCC / CH2Cl2 / 2 h / Ambient temperature
2: 2.) silica gel / 1.) CH2Cl2, 10-15 deg C, irradiation, 30 min, 2.) EtOAc, hexane
View Scheme
参考文献
Poigny, Stephane; Guyot, Michele; Samadi, Mohammad
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 15 p. 2175 - 2177
反应条件
1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C
2: acetic anhydride / 2 h / Reflux
View Scheme
参考文献
Kshirsagar, Umesh A.; Argade, Narshinha P.
Synthesis, 2011 , # 11 p. 1804 - 1808
反应条件
1.1: tributylphosphine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
2.2: 0.75 h / Cooling
3.1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C
4.1: acetic anhydride / 2 h / Reflux
View Scheme
参考文献
Kshirsagar, Umesh A.; Argade, Narshinha P.
Synthesis, 2011 , # 11 p. 1804 - 1808
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
1.2: 0.75 h / Cooling
2.1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C
3.1: acetic anhydride / 2 h / Reflux
View Scheme
参考文献
Kshirsagar, Umesh A.; Argade, Narshinha P.
Synthesis, 2011 , # 11 p. 1804 - 1808
反应条件
acetic anhydride
2 h; Reflux;
参考文献
Kshirsagar, Umesh A.; Argade, Narshinha P.
Synthesis, 2011 , # 11 p. 1804 - 1808
反应条件
silica gel
1.) CH2Cl2, 10-15 deg C, irradiation, 30 min, 2.) EtOAc, hexane; Yield given. Multistep reaction;
参考文献
Poigny, Stephane; Guyot, Michele; Samadi, Mohammad
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 15 p. 2175 - 2177
