1-(4-吡啶基)-1,3-丁二酮合成路线 （共 11 条）
反应条件
1: NH2OH*HCl, Na2CO3 / aq. ethanol View Scheme
参考文献
Bauer,V.J. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 5 p. 984 - 986
反应条件
1: NH2OH*HCl, Na2CO3 / aq. ethanol View Scheme
参考文献
Bauer,V.J. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 5 p. 984 - 986
反应条件
1: NH2OH*HCl, Na2CO3 / aq. ethanol View Scheme
参考文献
Bauer,V.J. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 5 p. 984 - 986
参考文献
Tscherne
Monatshefte fuer Chemie, 1901 , vol. 22, p. 621
反应条件
formic acid; zinc 6.5 h; Heating;
参考文献
Ferles, Miloslav; Kafka, Stanislav; Silhankova, Alexandra; Sputova, Michaela
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 5 p. 1167 - 1172
反应条件
1: With sodium methylate in diethyl ether
6 h; Heating / reflux;
2: With water; acetic acid
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/17932 A2, 2008 ;
Location in patent: Page/Page column 92 ;
反应条件
1: isonicotinic acid ethyl ester With sodium hydride in hexane; N,N-dimethyl-formamide; mineral oil
T=20°C; 1 h;
2: acetone in hexane; N,N-dimethyl-formamide; mineral oil
T=20°C; 18 h;
参考文献
Andres, Miriam; Bravo, Monica; Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Eichhorn, Peter; Ferrer, Manel; Lehner, Martin D.; Moreno, Imma; Roberts, Richard S.; Sevilla, Sara
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 168 - 184
反应条件
hydrogenchloride in water
T=80°C; 1 h;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17687 - 17691
反应条件
1.1: dichloro(cycloocta-1,5-diene)palladium(II); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; triethylamine / 1,4-dioxane / 80 °C / |Glovebox; |Inert atmosphere
1.2: 80 °C / |Glovebox; |Inert atmosphere
1.3: 18 h / 80 °C
2.1: hydrogenchloride / water / 1 h / 80 °C
View Scheme
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17687 - 17691
反应条件
diethyl ether; sodium ethanolate
参考文献
Tscherne
Monatshefte fuer Chemie, 1901 , vol. 22, p. 621
