2-溴-5-甲氧基苯甲醛合成路线 （共 53 条）
反应条件
1: Na2CO3 / Pd(OAc)2 / dimethylformamide; H2O / 12 h / 25 °C 2: MgSO4 / toluene / 100 °C 3: cesium pivalate / Pd(OAc)2; 1,1-bis(diphenylphosphino)methane / dimethylformamide / 12 h / 100 °C 4: aq. HCl / acetone View Scheme
参考文献
Zhao, Jian; Yue, Dawei; Campo, Marino A.; Larock, Richard C.
Journal of the American Chemical Society, 2007 , vol. 129, # 16 p. 5288 - 5295
反应条件
sodium acetate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=120°C; Suzuki coupling; 16 h; Inert atmosphere;
参考文献
Paul, Sunanda; Samanta, Shubhankar; Ray, Jayanta K.
Tetrahedron Letters, 2010 , vol. 51, # 42 p. 5604 - 5608
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 76 percent / tetrahydrofuran; hexane / 0 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 2.2: 78 percent / tetrahydrofuran; hexane / -78 °C 3.1: n-BuLI / tetrahydrofuran; hexane / 0.5 h / -78 °C 3.2: 88 percent / tetrahydrofuran; hexane / -78 °C 4.1: 90 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 1 h / 20 °C 5.1: 81 percent / MS 4 Angstroem / Zn(OTf)2 / toluene / 3 h / 90 °C View Scheme
参考文献
Lin, Ming-Yuan; Das, Arindam; Liu, Rai-Shung
Journal of the American Chemical Society, 2006 , vol. 128, # 29 p. 9340 - 9341
反应条件
1: NH2OH*HCl; pyridine / ethanol 2: 64 percent / PEG-supported methyl N-(triethylammonium-sulfonyl)carbamate / tetrahydrofuran / Heating View Scheme
参考文献
Miller; Kaufman
Synlett, 2000 , # 8 p. 1169 - 1171
反应条件
ethanol; platinum; iron(II) chloride Hydrogenation;
参考文献
Fukuyama, Yoshiyasu; Yaso, Hideyuki; Nakamura, Kazuhiko; Kodama, Mitsuaki
Tetrahedron Letters, 1999 , vol. 40, # 1 p. 105 - 108
反应条件
hydrogen bromide; acetic acid T=100°C; Hydrolysis; 3 h;
参考文献
Claudi, Francesco; Di Stefano, Antonio; Napolitani, Fabrizio; Cingolani, Gian Mario; Giorgioni, Gianfabio; Fontenla, Jose A.; Montenegro, Gisela Y.; Rivas, Maria E.; Rosa, Elizabeth; Michelotto, Barbara; Orlando, Giustino; Brunetti, Luigi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 599 - 608
反应条件
permanganate(VII) ion; acetone
参考文献
Horton,W.J.; Robertson,D.E.
Journal of Organic Chemistry, 1960 , vol. 25, p. 1016 - 1020
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
反应条件
1: 100 percent / Pd(PPh3)2Cl2; Et3N; CuI / Heating
2: 97 percent / tetrahydrofuran / 3 h / -78 °C
3: Et3N / tetrahydrofuran / 0 - 20 °C
4: 0.70 g / LiEt3BH / tetrahydrofuran / 18 h / 60 °C
5: 77 percent / [1,3-dimesitylimidazolidin-2-yl]Cl2(PCy3)Ru=CHPh / CH2Cl2 / 6 h / Heating
View Scheme
参考文献
Rosillo, Marta; Dominguez, Gema; Casarrubios, Luis; Amador, Ulises; Perez-Castells, Javier
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2084 - 2093
反应条件
1.1: TSA / benzene / 24 h / Heating
2.1: tetrahydrofuran / -78 °C
2.2: 76 percent / tetrahydrofuran
3.1: 81 percent / HCl / 12 h
View Scheme
参考文献
Sanchez-Larios, Eduardo; Holmes, Janice M.; Daschner, Crystal L.; Gravel, Michel
Organic Letters, 2010 , vol. 12, # 24 p. 5772 - 5775
