6,7,8,9-四氢-3-硝基-5H-苯并庚烯酮合成路线 （共 6 条）
反应条件
1.1: 84 percent / Sn; aq. HCl / ethanol / 0.5 h / Heating 2.1: aq. NaNO2; aq. HCl / 0 °C 2.2: 79 percent / CuCl; aq. HCl / 0 - 20 °C View Scheme
参考文献
Murineddu, Gabriele; Ruiu, Stefania; Loriga, Giovanni; Manca, Ilaria; Lazzari, Paolo; Reali, Roberta; Pani, Luca; Toma, Lucio; Pinna, Gerard A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7351 - 7362
反应条件
hydrogenchloride; tin in ethanol 0.5 h; Heating;
参考文献
Murineddu, Gabriele; Ruiu, Stefania; Loriga, Giovanni; Manca, Ilaria; Lazzari, Paolo; Reali, Roberta; Pani, Luca; Toma, Lucio; Pinna, Gerard A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7351 - 7362
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr; 1 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69832 A2, 2004 ;
Location in patent: Page 85 ;
反应条件
sulfuric acid; potassium nitrate
T=15°C; 1 h;
参考文献
MITSUBISHI PHARMA CORPORATION
Patent: WO2004/87124 A1, 2004 ;
Location in patent: Page/Page column 50 ;
WO 2004/087124 A1
反应条件
nitric acid; acetic acid
T=10°C;
参考文献
Brocklehurst, Cara E.; Lehmann, Hansjoerg; La Vecchia, Luigi
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1447 - 1453
反应条件
1: hydrogenchloride; tin / ethanol / 0.83 h / |Reflux
2: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
View Scheme
参考文献
ACADEMIA SINICA; WONG, Chi-Huey; FANG, Jim-Min; SHIE, Jiun-Jie
Patent: WO2014/31762 A1, 2014 ;
