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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
替马罗汀
合成路线
（共 16 条）
1398115-53-1
+
38111-44-3
苯基溴化锌
→
反应条件
75078-91-0
替马罗汀
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran 2.5 h; Inert atmosphereReflux;
参考文献
Guerrero Jr., Palimecio G.; De Oliveira, Paulo R.; Baroni, Adriano C.M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5302 - 5305
83832-05-7
+
27452-17-1
6-溴-1,1,4,4-四甲基-1,2,3,4-四氢化萘
→
反应条件
75078-91-0
替马罗汀
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine in N,N-dimethyl-formamide T=80°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Kim, Hye Ryung; Yun, Jaesook
Chemical Communications, 2011 , vol. 47, # 10 p. 2943 - 2945
100-52-7
苯甲醛
+
69251-24-7
→
反应条件
75078-91-0
替马罗汀
反应条件
tetrahydrofuran T=65°C; 12 h;
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
17610-21-8
1-(5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)乙烷-1-酮
→
反应条件
75078-91-0
替马罗汀
反应条件
1: sodium borohydride / methanol / 1.5 h / 0 °C 2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 3: diethyl ether; xylene / 48 h / 100 °C 4: 45 percent / butylene oxide / 12 h / 65 °C View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
69251-25-8
→
反应条件
75078-91-0
替马罗汀
反应条件
1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C 2: diethyl ether; xylene / 48 h / 100 °C 3: 45 percent / butylene oxide / 12 h / 65 °C View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
1283231-56-0
→
反应条件
75078-91-0
替马罗汀
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; triphenylphosphine / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; triphenylphosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme
参考文献
Kim, Hye Ryung; Yun, Jaesook
Chemical Communications, 2011 , vol. 47, # 10 p. 2943 - 2945
18826-59-0
→
反应条件
75078-91-0
替马罗汀
反应条件
1.1: potassium tert-butylate; tris-(o-tolyl)phosphine; copper(l) chloride / tetrahydrofuran / 0.17 h / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; triphenylphosphine / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere 3.1: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; triphenylphosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere View Scheme
参考文献
Kim, Hye Ryung; Yun, Jaesook
Chemical Communications, 2011 , vol. 47, # 10 p. 2943 - 2945
69251-26-9
→
反应条件
75078-91-0
替马罗汀
反应条件
1: diethyl ether; xylene / 48 h / 100 °C 2: 45 percent / butylene oxide / 12 h / 65 °C View Scheme
参考文献
Loeliger; Bollag; Mayer
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 9 - 15
119362-54-8
→
反应条件
75078-91-0
替马罗汀
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C 1.2: 20 °C 2.1: tetrahydrofuran; hexane / 0.17 h / 0 - 20 °C / |Inert atmosphere 2.2: 2 h / |Reflux; |Inert atmosphere 3.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 4.1: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 5.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 2.5 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Guerrero Jr., Palimecio G.; De Oliveira, Paulo R.; Baroni, Adriano C.M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5302 - 5305
1398115-52-0
→
反应条件
75078-91-0
替马罗汀
反应条件
1: tetrahydrofuran; hexane / 0.17 h / -78 °C / |Inert atmosphere 2: tetrahydrofuran; hexane / 0.5 h / |Inert atmosphere 3: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / tetrahydrofuran / 2.5 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Guerrero Jr., Palimecio G.; De Oliveira, Paulo R.; Baroni, Adriano C.M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5302 - 5305
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