2,3,4,6-四甲氧基苯乙酮合成路线 （共 22 条）
反应条件
1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 10 h / 50 °C / Inert atmosphere 2: potassium carbonate / methanol / 3 h / 20 °C / Inert atmosphere 3: potassium carbonate / acetone / 9.5 h / 20 °C / Inert atmosphere 4: AlCl3, aluminium chloride / dichloromethane / 0 - 20 °C 5: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere 6: trifluoroacetic acid / methanol / 24 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 10 p. 2868 - 2870
反应条件
1: selenium(IV) oxide; dihydrogen peroxide / tert-butyl alcohol / 10 h / 50 °C / Inert atmosphere 2: potassium carbonate / methanol / 3 h / 20 °C / Inert atmosphere 3: potassium carbonate / acetone / 9.5 h / 20 °C / Inert atmosphere 4: AlCl3, aluminium chloride / dichloromethane / 0 - 20 °C 5: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere 6: trifluoroacetic acid / methanol / 24 h / 50 °C 7: AlCl3, aluminium chloride; ethanethiol / CHCl2 / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 10 p. 2868 - 2870
反应条件
copper(ll) bromide T=40 - 50°C; 2.5 h; Yield given;
参考文献
Horie, Tokunaru; Tsukayama, Masao; Kawamura, Yasuhiko; Yamamoto, Shigeo
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 11 p. 4465 - 4472
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1.5 h; Inert atmosphere;
参考文献
Asakawa, Tomohiro; Hiza, Aiki; Nakayama, Miho; Inai, Makoto; Oyama, Dai; Koide, Hiroyuki; Shimizu, Kosuke; Wakimoto, Toshiyuki; Harada, Norihiro; Tsukada, Hideo; Oku, Naoto; Kan, Toshiyuki
Chemical Communications, 2011 , vol. 47, # 10 p. 2868 - 2870
反应条件
aluminium trichloride
参考文献
Chapman; Perkin; Robinson
Journal of the Chemical Society, 1927 , p. 3020
Show Details
Hattori
Acta Phytochimica, 1930 , vol. 5, p. 103,110
Chem. Zentralbl., 1931 , vol. 102, # I p. 1760
Show Details
Hayashi
Acta Phytochimica, 1933 , vol. 7, p. 117,138
Acta Phytochimica, 1934 , vol. 8, p. 65,93
Show Details
Bargellini; Zoras
Gazzetta Chimica Italiana, 1934 , vol. 64, p. 192,197; s.a. E I 732; E II 533
反应条件
potassium carbonate in acetone
17 h; Heating;
参考文献
Rizzi, George P.
Synthetic Communications, 1983 , vol. 13, # 14 p. 1173 - 1180
反应条件
In(OSO2CF3)3
T=85 - 95°C; Friedel-Crafts acetylation; 0.05 h; IrradiationMicrowave;
参考文献
Tsukayama, Masao; Kusunoki, Eiji; Hossain, Mohammad M.; Kawamura, Yasuhiko; Hayashi, Shinji
Heterocycles, 2007 , vol. 71, # 7 p. 1589 - 1600
反应条件
1: 96 percent / H2 / Raney Ni / methanol / 20 °C
2: 84 percent / K2CO3 / acetone / 0.08 h / 73 °C / microwave irradiation
3: 3.66 g / AlCl3 / diethyl ether / 1.5 h / 0 °C
View Scheme
参考文献
Tsukayama, Masao; Kawamura, Yasuhiko; Ishizuka, Takaaki; Hayashi, Shinji; Torii, Fumihito
Heterocycles, 2003 , vol. 60, # 12 p. 2775 - 2784
反应条件
1: 1.38 g / AlCl3 / diethyl ether / 2 h / 22 °C
2: 84 percent / K2CO3 / acetone / 17 h / Heating
View Scheme
参考文献
Rizzi, George P.
Synthetic Communications, 1983 , vol. 13, # 14 p. 1173 - 1180
反应条件
1: 84 percent / K2CO3 / acetone / 0.08 h / 73 °C / microwave irradiation
2: 3.66 g / AlCl3 / diethyl ether / 1.5 h / 0 °C
View Scheme
参考文献
Tsukayama, Masao; Kawamura, Yasuhiko; Ishizuka, Takaaki; Hayashi, Shinji; Torii, Fumihito
Heterocycles, 2003 , vol. 60, # 12 p. 2775 - 2784
