N-(1,3-二甲基-1H-吡唑-5-基)乙酰胺合成路线 （共 4 条）
反应条件
1.1: potassium hydroxide / acetone / 0.17 h / |Reflux 1.2: 1 h / |Reflux 2.1: potassium hydroxide / ethanol; water / 10 h / |Reflux View Scheme
参考文献
Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Daidone, Giuseppe
Molecules, 2013 , vol. 18, # 10 p. 13096 - 13110
反应条件
pyridine
T=0 - 20°C; 0.5 h;
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 172 ;
反应条件
in ethyl acetate
T=25°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/153589 A1, 2009 ;
Location in patent: Page/Page column 222 ;
WO 2009/153589 A1
反应条件
1: With trichlorophosphate
T=90 - 95°C; 2 h;
2: With N,N-dimethyl-formamide
T=90 - 95°C; 3.3 h; Product distribution / selectivity;
参考文献
REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu
Patent: WO2006/73973 A2, 2006 ;
Location in patent: Page/Page column 172-173 ;
