N,N-二甲基-1H-吲哚-2-甲酰胺合成路线 （共 7 条）
反应条件
1: LiAlH4; THF 2: ethanol; sodium View Scheme
参考文献
Kornfeld
Journal of Organic Chemistry, 1951 , vol. 16, p. 806,808
反应条件
1: 1H-indole-2-carboxylic acid With thionyl chloride in tetrahydrofuran
T=20°C; 16 h;
2: dimethyl amine in dichloromethane; water
T=20°C; 0.166667 h;
参考文献
Perez, Edwin G.; Cassels, Bruce K.; Eibl, Christoph; Guendisch, Daniela
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3719 - 3727
参考文献
Kornfeld
Journal of Organic Chemistry, 1951 , vol. 16, p. 806,808
反应条件
1: SOCl2 / benzene; dimethylformamide / 50 °C
2: benzene / 20 °C
View Scheme
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
反应条件
1: 1) BuLi / 1) THF, -78 deg C to r.t., 2) THF, - 78 deg C
2: 1) tert-BuLi / 1) THF, -78 deg C, 30-90 min, 2) to r.t., 6 h
View Scheme
参考文献
Gharpure; Stoller; Bellamy; Firnau; Snieckus
Synthesis, 1991 , # 12 p. 1079 - 1082
反应条件
lithium diisopropyl amide
1) THF, -70 deg C, 30 min., 2) -30 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bennasar, M.-Lluisa; Zulaica, Ester; Bosch, Joan
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2835 - 2841
反应条件
tert.-butyl lithium
1) THF, -78 deg C, 30-90 min, 2) to r.t., 6 h; Yield given. Multistep reaction;
参考文献
Gharpure; Stoller; Bellamy; Firnau; Snieckus
Synthesis, 1991 , # 12 p. 1079 - 1082
