1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸 3-(2-氰基乙基) 5-甲基酯合成路线 （共 8 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide 5 h; Ambient temperature;
参考文献
Ogawa; Hatayama; Maeda; Kita
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 8 p. 1579 - 1589
反应条件
hydrogenchloride; sodium hydroxide in water; acetone
参考文献
Laboratoires Syntex S.A.
Patent: US4761420 A1, 1988 ;
反应条件
in methanol
2 h; Reflux;
参考文献
Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya
Molecules, 2014 , vol. 19, # 1 p. 1344 - 1352
反应条件
in isopropyl alcohol
7 h; Heating; Yield given;
参考文献
Ashimori; Uchida; Ohtaki; Tanaka; Ohe; Fukaya; Watanabe; Kaghitani; Yokoyama
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 108 - 111
反应条件
1: ammonium acetate / isopropyl alcohol / 15 h / 20 °C
2: methanol / 2 h / |Reflux
View Scheme
参考文献
Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya
Molecules, 2014 , vol. 19, # 1 p. 1344 - 1352
反应条件
1: ammonium acetate / isopropyl alcohol / 15 h / 20 °C
2: methanol / 2 h / |Reflux
View Scheme
参考文献
Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya
Molecules, 2014 , vol. 19, # 1 p. 1344 - 1352
反应条件
in isopropyl alcohol
5 h; Heating;
参考文献
Ogawa; Hatayama; Maeda; Kita
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 8 p. 1579 - 1589
反应条件
1: sodium hydroxide / ethylene glycol dimethyl ether / 2 h / 20 °C
2: CN / water; N,N-dimethyl-formamide / 24 h / 20 - 120 °C
3: phosphorus pentachloride / dichloromethane / 1 h / -20 °C
4: dichloromethane / 4 h / -30 °C
View Scheme
参考文献
Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya
Molecules, 2014 , vol. 19, # 1 p. 1344 - 1352
