3-甲氧基-1,2-二甲基-9H-咔唑-4-醇合成路线 （共 24 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=25°C; Reduction; 1.5 h;
参考文献
Knoelker, Hans-Joachim; Froehner, Wolfgang
Tetrahedron Letters, 1999 , vol. 40, # 38 p. 6915 - 6918
反应条件
sodium hydroxide in methanol; water
T=92°C; 3 h;
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in 1,4-dioxane
4 h; Heating;
参考文献
Beccalli; Marchesini; Pilati
Tetrahedron, 1996 , vol. 52, # 8 p. 3029 - 3036
反应条件
2: KOH / ethanol
3: 94 percent / aq. NaOH, tetrabutylammonium bromide / CH2Cl2 / 16 h
4: 39 percent / Ph3SnH, AIBN / benzene / 6 h / Heating
5: 65 percent / sodium naphthalenide / tetrahydrofuran / 0.03 h
6: 71 percent / 10percent Pd/C / various solvent(s) / 56 h / 210 °C
View Scheme
参考文献
Clive; Etkin; Joseph; Lown
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2442 - 2445
反应条件
1: 94 percent / aq. NaOH, tetrabutylammonium bromide / CH2Cl2 / 16 h
2: 39 percent / Ph3SnH, AIBN / benzene / 6 h / Heating
3: 65 percent / sodium naphthalenide / tetrahydrofuran / 0.03 h
4: 71 percent / 10percent Pd/C / various solvent(s) / 56 h / 210 °C
View Scheme
参考文献
Clive; Etkin; Joseph; Lown
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2442 - 2445
反应条件
1: KOH / ethanol
2: 94 percent / aq. NaOH, tetrabutylammonium bromide / CH2Cl2 / 16 h
3: 39 percent / Ph3SnH, AIBN / benzene / 6 h / Heating
4: 65 percent / sodium naphthalenide / tetrahydrofuran / 0.03 h
5: 71 percent / 10percent Pd/C / various solvent(s) / 56 h / 210 °C
View Scheme
参考文献
Clive; Etkin; Joseph; Lown
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2442 - 2445
反应条件
1: 39 percent / Ph3SnH, AIBN / benzene / 6 h / Heating
2: 65 percent / sodium naphthalenide / tetrahydrofuran / 0.03 h
3: 71 percent / 10percent Pd/C / various solvent(s) / 56 h / 210 °C
View Scheme
参考文献
Clive; Etkin; Joseph; Lown
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2442 - 2445
参考文献
Moody, Christopher J.; Shah, Pritom
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 376 - 377
反应条件
1: 55 percent
2: 99 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 25 °C
View Scheme
参考文献
Knoelker, Hans-Joachim; Froehner, Wolfgang
Tetrahedron Letters, 1999 , vol. 40, # 38 p. 6915 - 6918
反应条件
1: 98 percent / pyridine; DMAP / 10 h / 20 °C
2: 79 percent / AcOH; Fe; FeCl3*6H2O / ethanol / 4 h / Heating
3: 89 percent / pyridine / 4 h / 20 °C
4: 40 percent / (PhSe)2; Bu3SnH; AIBN / 85 °C
5: 74 percent / CH2Cl2 / -78 - 20 °C
6: 53 percent / t-BuOOH / benzene; H2O / 2.5 h / Heating
7: 75 percent / NaOH / methanol; H2O / 3 h / 92 °C
View Scheme
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
