3-甲氧基-1,2-二甲基-9H-咔唑-4-醇合成路线 （共 24 条）
反应条件
1: 89 percent / pyridine / 4 h / 20 °C
2: 40 percent / (PhSe)2; Bu3SnH; AIBN / 85 °C
3: 74 percent / CH2Cl2 / -78 - 20 °C
4: 53 percent / t-BuOOH / benzene; H2O / 2.5 h / Heating
5: 75 percent / NaOH / methanol; H2O / 3 h / 92 °C
View Scheme
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
反应条件
1: 79 percent / AcOH; Fe; FeCl3*6H2O / ethanol / 4 h / Heating
2: 89 percent / pyridine / 4 h / 20 °C
3: 40 percent / (PhSe)2; Bu3SnH; AIBN / 85 °C
4: 74 percent / CH2Cl2 / -78 - 20 °C
5: 53 percent / t-BuOOH / benzene; H2O / 2.5 h / Heating
6: 75 percent / NaOH / methanol; H2O / 3 h / 92 °C
View Scheme
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
反应条件
1: 40 percent / (PhSe)2; Bu3SnH; AIBN / 85 °C
2: 74 percent / CH2Cl2 / -78 - 20 °C
3: 53 percent / t-BuOOH / benzene; H2O / 2.5 h / Heating
4: 75 percent / NaOH / methanol; H2O / 3 h / 92 °C
View Scheme
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
反应条件
1: 74 percent / CH2Cl2 / -78 - 20 °C
2: 53 percent / t-BuOOH / benzene; H2O / 2.5 h / Heating
3: 75 percent / NaOH / methanol; H2O / 3 h / 92 °C
View Scheme
参考文献
Crich, David; Rumthao, Sochanchingwung
Tetrahedron, 2004 , vol. 60, # 7 p. 1513 - 1516
反应条件
1: 90 percent / 48 h / 125 °C
2: 74 percent / aq. NaOH / methanol / 3 h / Heating
3: 75 percent / Red-Al / dioxane / 4 h / Heating
View Scheme
参考文献
Beccalli; Marchesini; Pilati
Tetrahedron, 1996 , vol. 52, # 8 p. 3029 - 3036
反应条件
1: 74 percent / aq. NaOH / methanol / 3 h / Heating
2: 75 percent / Red-Al / dioxane / 4 h / Heating
View Scheme
参考文献
Beccalli; Marchesini; Pilati
Tetrahedron, 1996 , vol. 52, # 8 p. 3029 - 3036
反应条件
2: 90 percent / NaOH (10percent) / H2O / 1.5 h / Heating
View Scheme
参考文献
Knolker; Bauermeister
Helvetica Chimica Acta, 1993 , vol. 76, # 7 p. 2500 - 2514
反应条件
2: 10percent NaOH / H2O / 1.5 h / Heating
View Scheme
参考文献
Knolker; Bauermeister
Journal of the Chemical Society - Series Chemical Communications, 1989 , # 19 p. 1468 - 1470
反应条件
1: 95 percent / K2CO3 / acetone / Heating
2: 4-dimethylaminopyridine / acetonitrile
3: 95 percent / N-bromosuccinimide / acetonitrile
4: 1.) BuLi, 2.) B(OMe)3, 3.) alkaline H2O2
5: 98 percent / 180 - 190 °C
View Scheme
参考文献
Moody, Christopher J.; Shah, Pritom
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 376 - 377
反应条件
1: 4-dimethylaminopyridine / acetonitrile
2: 95 percent / N-bromosuccinimide / acetonitrile
3: 1.) BuLi, 2.) B(OMe)3, 3.) alkaline H2O2
4: 98 percent / 180 - 190 °C
View Scheme
参考文献
Moody, Christopher J.; Shah, Pritom
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 376 - 377
