1-(3,4-二氯苯基)-3-二甲基氨基-1-丙酮盐酸盐合成路线 （共 4 条）
反应条件
1: in ethanol; water
3 h; Reflux;
2: With hydrogenchloride in ethyl acetate
参考文献
Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali
Patent: US2013/72488 A1, 2013 ;
Location in patent: Paragraph 0165 ;
反应条件
hydrogenchloride in ethanol
Mannich reaction; Heating;
参考文献
Du, Xiaohui; Guo, Chun; Hansell, Elizabeth; Doyle, Patricia S.; Caffrey, Conor R.; Holler, Tod P.; McKerrow, James H.; Cohen, Fred E.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2695 - 2707
反应条件
1: AlCl3, aluminium chloride / 8 h / 70 °C
2: ethanol; water / 3 h / |Reflux
View Scheme
参考文献
Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali
Patent: US2013/72488 A1, 2013 ;
反应条件
1: 1.) aq. Na2CO3, 2.) HBr / 2) acetone, ether
2: 95 percent / phosphate buffer / CHCl3 / 1.5 h / 37 °C / pH 7.4
View Scheme
参考文献
Dimmock; Shyam; Hamon; Logan; Raghavan; Harwood; Smith
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 8 p. 887 - 894
