(S)-(-)-1-三苯甲基-2-氮丙啶羧酸甲酯合成路线 （共 24 条）
反应条件
methyl 4-hydroxy-benzoate; triphenylphosphine; diethylazodicarboxylate in benzene 15 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2544 - 2546
反应条件
1: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; Metallation; 0.5 h; 2: (2R)-N-triphenylmethyl-3-iodoalanine methyl ester in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=40°C; Substitution; cyclization; 12 h; Title compound not separated from byproducts;
参考文献
Dugave, Christophe; Menez, Andre
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6067 - 6070
反应条件
in tetrahydrofuran T=40°C;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 9 p. 1453 - 1465
反应条件
caesium carbonate in N,N-dimethyl-formamide 4 h;
参考文献
Tetrahedron, , vol. 58, # 44 p. 9101 - 9109
反应条件
triphenylphosphine; diethylazodicarboxylate in benzene 15 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2544 - 2546
反应条件
1: triethylamine / CHCl3 / 0 - 20 °C 2: 97.0 g / triethylamine; 4-(dimethylamino)pyridine; methanesulfonyl chloride / 20 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 37, # 12 p. 2019 - 2030
反应条件
caesium carbonate in N,N-dimethyl-formamide 2 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 9 p. 1453 - 1465
反应条件
1: pyridine / 18 h / 0 °C 2: Et3N / tetrahydrofuran / 22 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 29 p. 9891 - 9900
反应条件
chloroform Behandeln mit Tritylchlorid und Methansulfonylchlorid und Erwaermen des Reaktionsgemisches unter Zusatz von Methanol;
参考文献
Experientia, , vol. 13, p. 291
Collection of Czechoslovak Chemical Communications, , vol. 22, p. 262,270
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: (S)-1-trityl-aziridine-2-carboxylic acid methyl ester in tetrahydrofuran; hexane T=-78°C; Claisen condensation; 12 h;
参考文献
Boesche, Uwe; Nubbemeyer, Udo
Tetrahedron, 1999 , vol. 55, # 22 p. 6883 - 6904
