(3R,4R)-1-苄基-3,4-二羟基吡咯烷-2,5-二酮合成路线 （共 11 条）
反应条件
in o-xylene Heating;
参考文献
Kano, Taichi; Hato, Yoshio; Maruoka, Keiji
Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8467 - 8469
反应条件
in xylene T=150°C; 3 h; Heating / reflux;
参考文献
EP1577301 A1, ;
Page/Page column 162 ;
反应条件
1: 1.3N HCl / 16 h / Ambient temperature 2: 1.) 30percent HBr, 2.) Ac2O / 1.) acetic acid, 50 deg C, 5 h, 2.) 50 deg C, 20 h, 3.) MeOH, RT, 42 h, then 45 deg C, 6 h View Scheme
参考文献
Heterocycles, , vol. 43, # 2 p. 415 - 423
反应条件
hydrogen bromide; acetic anhydride 1.) acetic acid, 50 deg C, 5 h, 2.) 50 deg C, 20 h, 3.) MeOH, RT, 42 h, then 45 deg C, 6 h; Multistep reaction;
参考文献
Heterocycles, , vol. 43, # 2 p. 415 - 423
反应条件
in o-xylene 7 h; RefluxInert atmosphere; optical yield given as percent de;
参考文献
Synthesis, , # 5 art. no. T17509SS, p. 791 - 796
参考文献
Tetrahedron Letters, , vol. 32, # 28 p. 3401 - 3404
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran T=20°C;
参考文献
Rejman, Dominik; Kocalka, Petr; Budesinsky, Milos; Pohl, Radek; Rosenberg, Ivan
Tetrahedron, 2007 , vol. 63, # 5 p. 1243 - 1253
反应条件
1: 83 percent / imidazole / dimethylformamide / 12 h / 25 °C 2: 81.7 percent / tetrahydrofuran / 6 h / 0 °C 3: 88 percent / BF3*OEt2; Et3SiH / CH2Cl2 4: 88 percent / Me2S*BH3 / tetrahydrofuran / 20 °C 5: 93 percent / TBAF / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Jeong, Hyung Jae; Lee, Ju Man; Kim, Min Kyu; Lee, Sang-Gyeong
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1019 - 1024
反应条件
lithium aluminium tetrahydride
参考文献
Couty, Francois; David, Olivier R. P.
Synlett, 2009 , # 12 p. 1945 - 1948
反应条件
1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 0 °C
2: triethylamine / dichloromethane
3: sodium azide / N,N-dimethyl-formamide / 100 °C
View Scheme
参考文献
Andrews, Kim M.; Beebe, David A.; Benbow, John W.; Boyer, David A.; Doran, Shawn D.; Hui, Yu; Liu, Shenping; McPherson, R. Kirk; Neagu, Constantin; Parker, Janice C.; Piotrowski, David W.; Schneider, Steven R.; Treadway, Judith L.; Vanvolkenberg, Maria A.; Zembrowski, William J.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1810 - 1814
