4-(N-叔丁氧羰基氨基)-1-丁醇合成路线 （共 21 条）
反应条件
(Ru2(η5-C5Ph4O)2(H)2(CO)4); N,N'-(3,3'-bis(propyl)methylamine)bis(salicylideneiminato)cobalt(II); 2,6-dimethoxy-p-benzoquinone in toluene T=100°C; P=760.051 Torr; 18 h;
参考文献
Babu, Beneesh P.; Endo, Yoshinori; Baeckvall, Jan-E.
Chemistry--A European Journal, 2012 , vol. 18, # 37 p. 11524 - 11527,4
反应条件
1: 77 percent / Ph3P, DEAD / tetrahydrofuran / Ambient temperature 2: 83 percent / Zn, 1.) M aq. KH2PO4 / tetrahydrofuran / 4 h / Ambient temperature 3: 95 percent / H2 / 10percent Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Arasujo, M. Joso S. M. P.; Ragnarsson, Ulf; Trigo, M. Joaquina S. A. Amaral; Almeida, M. Lurdes S.
Journal of Chemical Research, Miniprint, 1996 , # 8 p. 2143 - 2161
反应条件
1: triethylamine / toluene / 0.08 h / 0 °C 2: NaN3 / tetrabutylammonium bromide / toluene; H2O / 3 h / 60 °C View Scheme
参考文献
Synthesis, , p. 366 - 368
反应条件
methanesulfonyl chloride; triethylamine in DCM
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/71396 A2, 2007 ;
Location in patent: Page/Page column 134 ;
WO 2007/071396 A2
反应条件
triethylamine in dichloromethane T=0°C; 1.5 h;
参考文献
Shewalkar, Mukesh P.; Rao, Ramakrishna; Reddy, Veer Bhadra; Shinde, Devanand B.
Letters in Organic Chemistry, 2013 , vol. 10, # 7 p. 518 - 522
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran 3 h; Inert atmosphere;
参考文献
Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1151 - 1155
反应条件
triphenylphosphine in dichloromethane
参考文献
Kubo, Keiji; Miyawaki, Toshio; Kawamura, Masaki
Patent: US2003/187023 A1, 2003 ;
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide
T=20°C; 5.7 h;
参考文献
GEORGIA TECH RESEARCH CORPORATION
Patent: WO2005/80353 A1, 2005 ;
Location in patent: Page/Page column 30 ;
WO 2005/080353 A1
反应条件
1: 77 percent / Ph3P, DEAD / tetrahydrofuran / Ambient temperature
2: 83 percent / Zn, 1.) M aq. KH2PO4 / tetrahydrofuran / 4 h / Ambient temperature
3: 95 percent / H2 / 10percent Pd/C / methanol / 1 h / Ambient temperature
4: 75 percent / methanol / Ambient temperature
View Scheme
参考文献
Arasujo, M. Joso S. M. P.; Ragnarsson, Ulf; Trigo, M. Joaquina S. A. Amaral; Almeida, M. Lurdes S.
Journal of Chemical Research, Miniprint, 1996 , # 8 p. 2143 - 2161
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2, -70 deg C, 15 min, 2.) a) -70 deg C, 5 min, b) -70 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Sieng, Bora; Ventura, Oscar Lozano; Bellosta, Veronique; Cossy, Janine
Synlett, 2008 , # 8 p. 1216 - 1218
