5-(N-叔丁氧羰基氨基)-1-戊醇合成路线 （共 23 条）
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/177782 A1
反应条件
methanesulfonyl chloride; triethylamine in DCM
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/71396 A2, 2007 ;
Location in patent: Page/Page column 134 ;
WO 2007/071396 A2
反应条件
1: 82 percent / Ph3P, DEAD / tetrahydrofuran / Ambient temperature 2: 88 percent / H2 / 10percent Pd/C / methanol / 1 h / Ambient temperature 3: TFA / 1 h / Ambient temperature View Scheme
参考文献
Arasujo, M. Joso S. M. P.; Ragnarsson, Ulf; Trigo, M. Joaquina S. A. Amaral; Almeida, M. Lurdes S.
Journal of Chemical Research, Miniprint, 1996 , # 8 p. 2143 - 2161
反应条件
1: 98 percent / pyridine / CH2Cl2 / 1 h / 0 °C 2: 99 percent / NaN3 / dimethylformamide / 12 h / Ambient temperature View Scheme
参考文献
Lamanna, Giuseppe; Smulski, Cristian R.; Chekkat, Neila; Estieu-Gionnet, Karine; Guichard, Gilles; Fournel, Sylvie; Bianco, Alberto
Chemistry - A European Journal, 2013 , vol. 19, # 5 p. 1762 - 1768
反应条件
methanesulfonyl chloride; triethylamine in DCM
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/71396 A2, 2007 ;
Location in patent: Page/Page column 134 ;
WO 2007/071396 A2
反应条件
pyridine; Dess-Martin periodane in dichloromethane T=20°C; 0.5 h;
参考文献
Yu, Chengzhi; Hu, Longqin
Tetrahedron Letters, 2001 , vol. 42, # 31 p. 5167 - 5170
反应条件
water T=100°C; 4.5 h;
参考文献
Wang, Jia; Liang, Yan-Liang; Qu, Jin
Chemical Communications, 2009 , # 34 p. 5144 - 5146
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 4.5 h;
参考文献
Otsuki, Satsuki; Nishimura, Shinichi; Takabatake, Hisae; Nakajima, Kozue; Takasu, Yasuaki; Yagura, Toru; Sakai, Yuki; Hattori, Akira; Kakeya, Hideaki
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1608 - 1611
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; water
参考文献
Isis Pharmaceuticals, Inc.
Patent: US6191273 B1, 2001 ;
反应条件
(CuOTf)2*C6H5CH3 in tetrahydrofuran T=20°C; 1.5 h; Inert atmosphereMolecular sieve;
参考文献
Temperini, Andrea; Annesi, Diego; Testaferri, Lorenzo; Tiecco, Marcello
Tetrahedron Letters, 2011 , vol. 52, # 25 p. 3179 - 3182
