1-(苯并[d][1,3]二氧代-5-基)-2-溴-2-(6-甲基吡啶-2-基)乙酮合成路线 （共 3 条）
反应条件
N-bromosuccinmide in dichloromethane
T=20°C; 0.5 h;
参考文献
Pfizer Inc
Patent: US2004/176390 A1, 2004 ;
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -60 °C
1.2: 76 percent / tetrahydrofuran / 0.33 h / -60 °C
2.1: 92 percent / N-bromosuccinimide / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -60 °C
1.2: 76 percent / tetrahydrofuran / 0.33 h / -60 °C
2.1: 92 percent / N-bromosuccinimide / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
