L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
McIlvaine buffer; triethylamine; papain in ethyl acetate T=37°C; 72 h;
参考文献
Chen, S. T.; Wang, K. T.
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4589 - 4590
反应条件
potassium carbonate in water; acetic acid
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US5302743 A1, 1994 ;
反应条件
thermolysin in water T=40°C; pH=6.8, 4 iterations in the nucleophile pool; Yield given;
参考文献
Petkov, D. D.; Stoineva, I. B.
Tetrahedron Letters, 1984 , vol. 25, # 34 p. 3751 - 3754
反应条件
1: With potassium hydroxide in methanol 0.166667 h; Cooling with ice; 2: With hydroxylamine in methanol T=20°C; Inert atmosphere;
参考文献
Jankolovits, Joseph; Lim, Choong-Sun; Mezei, Gellert; Kampf, Jeff W.; Pecoraro, Vincent L.
Inorganic Chemistry, 2012 , vol. 51, # 8 p. 4527 - 4538
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.25 h / 0 °C 1.2: 24 h / 20 °C 2.1: sodium hydroxide / methanol / 10 h 3.1: trifluoroacetic acid / 2 h / 20 °C View Scheme
参考文献
Adhikari, Bimalendu; Kraatz, Heinz-Bernhard
Chemical Communications, 2014 , vol. 50, # 42 p. 5551 - 5553
反应条件
in ethanol T=20°C; 48 h; Inert atmosphere;
参考文献
Braese, Stefan; Volz, Nicole; Glaeser, Franziska; Nieger, Martin
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1385 - 1392
反应条件
1: ammonia (gas) / CHCl3 / 0.5 h / 0 °C 2: tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Pietrzynski, Grzegorz; Kubica, Zbigniew; Rzeszotarska, Barbara
Bulletin of the Polish Academy of Sciences, Chemistry, 1989 , vol. 37, # 9-12 p. 363 - 370
参考文献
Naef, Reto; Seebach, Dieter
Helvetica Chimica Acta, 1985 , vol. 68, p. 135 - 143
反应条件
sodium acetate; acetic acid in ethyl acetate
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US5302743 A1, 1994 ;
反应条件
sodium acetate; acetic anhydride in water; acetic acid
参考文献
Mitsui Toatsu Chemicals, Inc.
Patent: US5302743 A1, 1994 ;
