L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
triethylamine in dichloromethane T=25°C; Yield given;
参考文献
Zhu, Yun-Fei; Fuller, William D.
Tetrahedron Letters, 1995 , vol. 36, # 6 p. 807 - 810
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane 2 h; temperature: below 0 deg C;
参考文献
Matsuda, Fuyuhiko; Itoh, Shin; Hattori, Noritaka; Yanagiya, Mitsutoshi; Matsumoto, Takeshi
Tetrahedron, 1985 , vol. 41, # 18 p. 3625 - 3631
反应条件
sodium hydrogencarbonate; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride in water T=0°C; 2 h; optical yield given as percent de;
参考文献
Zajac, Krzysztof; Kaminski, Zbigniew J.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 6 p. 725 - 728
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in 1,4-dioxane 8 h; Ambient temperature; Yield given;
参考文献
Takeda; Ayabe; Suzuki; Konda; Harigaya
Synthesis, 1991 , # 9 p. 689 - 691
反应条件
1: NaHCO3 / H2O; tetrahydrofuran / Ambient temperature 2: diisobutylaluminium hydride / toluene; hexane / -77 °C 3: sodium metabisulfite / H2O / 5 h / Ambient temperature 4: 25percent aq. HCl / 12 h / 80 °C 5: 10N NaOH, Na2CO3 / H2O; tetrahydrofuran / Ambient temperature 6: KHCO3 / dimethylformamide / 12 h 7: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Yuan; Munoz; Wong; Haeggstrom; Wetterholm; Samuelsson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 211 - 220
反应条件
1: diethyl ether / 6 h / Heating 2: 69.3 g / pyridine / 12 h / 0 - 20 °C 3: 90 percent / potassium carbonate / ethanol / 1 h / Heating View Scheme
参考文献
Campbell, Craig D.; Concellon, Carmen; Smith, Andrew D.
Tetrahedron Asymmetry, 2011 , vol. 22, # 7 p. 797 - 811
反应条件
1: 83 percent / KHCO3; triethylamine / H2O; CHCl3 / 5 h / 0 °C 2: 98 percent / NaOH / methanol; tetrahydrofuran; H2O / 2 h / 0 °C View Scheme
参考文献
Pal, Asish; Ghosh, Yamuna K.; Bhattacharya, Santanu
Tetrahedron, 2007 , vol. 63, # 31 p. 7334 - 7348
反应条件
1: EDCI; HOBt; NMM / CH2Cl2 / 25 °C 2: LiOH*H2O / tetrahydrofuran; aq. methanol / 1 h / 25 °C View Scheme
参考文献
Organic Letters, , vol. 6, # 13 p. 2285 - 2287
反应条件
triethylamine in dichloromethane 12 h; Ambient temperature;
参考文献
Chemistry - A European Journal, , vol. 5, # 1 p. 79 - 89
反应条件
1.1: Et3N / methanol; diethyl ether / 2 h / -10 °C 1.2: 95 percent / NH3 / methanol / 48 h 2.1: 27 percent / Et3N / acetonitrile; methanol; tetrahydrofuran / 96 h / 20 °C 3.1: trifluoroacetic acid / 5 h / 20 °C View Scheme
参考文献
Laurent, Sophie; Botteman, Francois; Vander Elst, Luce; Muller, Robert N.
Helvetica Chimica Acta, 2004 , vol. 87, # 5 p. 1077 - 1089
