L-苯丙氨酸甲酯盐酸盐合成路线 （共 169 条）
反应条件
1: dicyclohexylcarbodiimide 2: NaOH / H2O / 3 h / 20 °C View Scheme
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
1: 1.) N-methylmorpholine, ClCO2iBu, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 2 min, 2.) THF, DMF, -15 deg C, 1 h 2: TFA / CH2Cl2 / 22 °C View Scheme
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
反应条件
hydrogenchloride; hydrogen in methanol; water T=20°C; P=760.051 Torr; 32 h;
参考文献
Synthesis, , # 14 art. no. Z02609SS, p. 2440 - 2446
反应条件
hydrogen; Nishimura catalyst <(45.9percent Rh/19.9percent Pt) oxide> in methanol T=25°C; P=75007.5 Torr;
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 8 p. 802 - 808
反应条件
1: 87 percent / triethylamine / CHCl3 / 0.5 h / Ambient temperature 2: 1.9 g / methanol / 12 h / 0 °C View Scheme
参考文献
Hlavacek, Jan; Fric, Ivo; Budesinsky, Milos; Blaha, Karel
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11A p. 2473 - 2494
反应条件
sodium hydroxide in methanol; water
参考文献
Pfizer Inc.
Patent: US4256897 A1, 1981 ;
反应条件
1: 58 percent / N-methyl-2-chloropyridinium iodide, Et3N / CH2Cl2 / 1 h / Heating 2: 0.25 h / 80 °C 3: aq. HCl / tetrahydrofuran / 20 °C 4: 65 mg / H2 / Pd(OH)2/C / ethanol; H2O / 5 h / 70 °C / 760 Torr View Scheme
参考文献
Anderson; Barton; Hardy; Kenner; Preston; Sheppard
Journal of the Chemical Society. Perkin transactions 1, 1967 , vol. 1, p. 108 - 113
反应条件
hydrogenchloride; sodium hydroxide 1.) water, 0-5 deg C, pH 8.5-9.5, 2.) MeOH, water, 0 deg C, pH 4.5-5; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Vinick, Fredic J.; Jung, Stanley
Tetrahedron Letters, 1982 , vol. 23, # 13 p. 1315 - 1318
反应条件
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 1.5 h / 0 °C 2.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 20 °C / pH 6 - 7 View Scheme
参考文献
Fu, Zhengyan; He, Jiangpeng; Tong, Aiping; Xie, Yongmei; Wei, Yuquan
Synthesis (Germany), 2013 , vol. 45, # 20 art. no. SS-2013-H0366-OP, p. 2843 - 2852
参考文献
Toyo Soda Manufacturing Co. Ltd.; (Zaidanhojin) Sagami Chemical Research Center
Patent: US4165311 A1, 1979 ;
